Metformin and Appetite

This is a very long story that at the moment I will keep very short.

At my annual physical 4 days ago I asked for a prescription of metformin – a diabetic drug. This is a treatment that the American Diabetic Association believes to be reasonable in the treatment of prediabetes to slow the onset of the actual disease.

Clinical trials have shown that people at high risk for developing diabetes can be given treatments that delay or prevent onset of diabetes. The first therapy should always be an intensive lifestyle modification program because weight loss and physical activity are much more effective than any medication at reducing diabetes risk.

Several drugs have been shown to reduce diabetes risk to varying degrees. No drug is approved by the U.S. Food and Drug Administration to treat insulin resistance or prediabetes or to prevent type 2 diabetes. The American Diabetes Association recommends that metformin is the only drug that should be considered for use in diabetes prevention. Other drugs that have delayed diabetes have side effects or haven’t shown long-lasting benefit. Metformin use was recommended only for very high-risk individuals who have both forms of prediabetes (IGT and IFG), have a BMI of at least 35, and are younger than age 60. In the DPP, metformin was shown to be most effective in younger, heavier patients.

I don’t think my doctor would have given it to me otherwise, but because I referenced the ADA’s view on it, he agreed, though maybe, just maybe, with a little annoyance. Note that my BMI is lower so I don’t exactly fit the profile.

My blood sugar, which hung out in the prediabetic range of 100 to 125 most of the time now resides mostly in the 80s.

Instantly, my appetite has changed. I feel like how I imagine ‘normal’ people feel when they eat. I eat, I am full, and I don’t think about food after. It is very, very early in all this, and I am not exactly thrilled to be on another medication, but what once seemed hard – avoiding the goodies – that pizza that calls my name from the kitchen at night – seems to have been quieted.

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